Research Scientist - In Vivo Pharmacology

The Opportunity

CSL has an exciting opportunity for a Research Scientist to join our In vivo Pharmacology Group at the Research site at Bio21, Parkville.

The In vivo Pharmacology Group is responsible for evaluating and understanding the mechanism of action of protein-based therapeutics in animal models of disease.

Reporting to the Respiratory Lead Senior Scientist, you will be responsible for evaluating, establishing, developing, and performing animal models of respiratory disease for the conduct of proof-of-concept and proof-of-mechanism studies. You will work with an extended team across different areas within CSL and external collaborations.

The Role

• Supervise and conduct proof-of-concept In vivo studies to generate data packages to support the development of selected drug candidates

• Supervise and conduct In vivo and in vitro experiments to understand the mechanism of action of selected drug candidates

• Contribute to the development of novel approaches to treat respiratory diseases and associated conditions

• Present research plans and data

• Ensure laboratory practices and animal ethics submissions meet required deadlines and comply with all relevant guidelines, standards and regulations

• Supervise and train junior staff in the above activities

Your skills and experience

• PhD in a relevant scientific discipline (e.g. respiratory biology, immunology, pharmacology) (OR) tertiary qualification with 5+ years of experience working with animal models of respiratory disease

• Experience with animal models of disease is essential, including animal handling, anaesthesia and surgery/dissection skills. Experience with respiratory and/or immunological mouse models will be viewed especially favourably. Experience in performing lung function measurements is desirable, but not essential

• Experience developing, breeding, and maintaining mouse strains

• Experience with at least two of the following in vitro assays: flow cytometry, ELISA, protein activity assays, Luminex arrays, histology, immunohistochemistry, fluorescence microscopy

• Experience with, or a working knowledge of, platform technologies such as immunohistochemistry and imaging, RNAseq or proteomics

• Proven ability in assay design, data analysis, and statistical analyses with good knowledge of software packages: Excel, Graphpad Prism. Experience with flow cytometry and imaging software is advantageous but not essential (e.g. FlowJo, Fiji)

• Ability to work both independently and as part of a broader multidisciplinary team, with flexibility to function in a continuously changing environment and under tight timelines.

How to Apply:

Please submit your application including a cover letter and CV by 22 February 2024.

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