Scientist - Purification Development

The Opportunity
This role is situated within the Purification Department of CSL's Biopharmaceutical Product Development function (CSL R&D), located in our state-of-the-art research facility at CSL’s Head Office in Melbourne, Australia. As a key member of our world-class purification laboratory, you will develop and scale up elegant , robust, and cost-effective purification schemes for monoclonal antibodies and recombinant proteins. Your work will be pivotal from supporting clinical studies to commercial launch.
The ideal candidate will possess practical knowledge of chromatography and filtration modalities, experience operating chromatography skids, and a working knowledge of technology transfer to pilot scale and clinical manufacturing facilities. You should have a sound understanding of Quality by Design and GxP principles.
This position reports either to the Senior Scientist or Manager of Purification Development and may involve supervision of Associate Scientists and student interns.
The Role

• Drive the development and optimisation of purification processes under the guidance of the Senior Scientist or Manager.
  
• Generate and manage accurate reliable data to support purification process development.
  
• Play a key role in process optimisation, scale-up, and technology transfer activities to the pilot scale operations group and to commercial manufacturing sites.
  
• Complete all allocated training and may be required to provide lab-based training in process procedures and equipment operations to other Associate Scientists and Scientists.
  
• Responsible for developing and executing laboratory housekeeping duties, and must maintain laboratories, equipment, and facilities to GSP and regulatory standards.
  
• Ensures high safety standards are adhered to individually, and by the team as governed by local, state, and federal regulations, laws, and policies as well as CSL’s policies and directives.
  
• Identifies opportunities for improvement and supports implementation in the team.
  
• Source and order required raw materials and equipment required to support experimental studies.
  
• Communication of ideas, plans, and results succinctly in both written and oral presentation, and effectively represents the purification group in project meetings.
  
• Undertake supporting role in the group for attainment of technical goals and adherence to project timelines.
  
• Required to author and review documents associated with process development including procedures, study protocols, reports and workbooks.
  
• Provide leadership and training that supports the professional development of Associate Scientists and interns.
  
• Responsible for setting personal work plans and managing self as appropriate
  

Your skills and experience

• PhD in Biotechnology, Biochemistry, Chemistry, Engineering, or related discipline, ideally with a relevant post-doc or first industry experience; Or Masters by Research degree with at least 5 years’ experience in process development relating to purification of therapeutic proteins for clinical use.
  
• Demonstrated record of scientific achievement in protein purification and understanding of modern principles of chromatography, filtration, and bioanalytical techniques.
  
• Proficient in the design of experiments and data processing (analysis, visualisation, interpretation, and reporting).
  
• Practical knowledge of robotic high-throughput protein purification technologies and computer programming languages would be an advantage.
  
• Working knowledge of Quality by Design and GxP principles
  

How to Apply
Please submit your application including resume and cover letter addressing the selection criteria listed under skills and experience above. Applications close on 14 February 2024.
Apply now to join a values-based, purpose-driven company committed to protecting public health! We offer a dynamic and innovative environment where your work will make a real difference.
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About CSL
CSL is a leading global biotechnology company with a dynamic portfolio of life-saving medicines, including those that treat haemophilia and immune deficiencies, as well as vaccines to prevent influenza. Since our start in 1916, we have been driven by our promise to save lives through innovation. Learn more about CSL.
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