Address6 - 10 years
Brisbane, CA
Full-time
Onsite
2 weeks ago Research Scientist, Neuroscience
Xaira Therapeutics
6 - 10 years
Brisbane, CA
Full-time
Onsite
2 weeks ago
About the role
About You The ideal candidate will have a strong and established background in neuroscience, experience in electrophysiology, neuronal isolation/derivation and culture, in vivo pain models, and a proven record of successfully leading diverse project teams to produce novel therapeutics. The candidate will have experience with project conception, strategic planning, budgeting, and both leading as well as contributing to cross-functional and matrixed teams. Additionally, the candidate will have a working knowledge of various research areas including neuroscience, biochemistry, toxicology, and histology. The candidate will be able to lead by influence and maintain a productive, collaborative, and inclusive laboratory environment in compliance with regulatory and company expectations.
Experience managing projects from early-stage research through development is required
. A key role for the position is partnering with senior management to conceive and provide strategic direction and vision for the program while leading a team responsible for executing the technical aspects of the plan. Strong communication skills are essential as the candidate must be able to tailor interactions with technical teams and represent the program and strategy to executive-level management. Key Responsibilities Develop and execute a neuroscience therapeutic strategy in alignment with corporate goals and key scientific objectives in drug discovery research. Drive drug discovery by leading team members in identifying and validating targets, designing and performing in vitro and in vivo assays, and analyzing results. Liaise with molecular design and generation, toxicology, immunology, bioanalytical, and clinical development colleagues. As programs advance, develop plans to address and reduce risks in collaboration with key stakeholders to help progress into clinical studies. Manage project activities and professional development of a team of scientists through effective mentoring, guidance, and supervision. Advance scientific expertise within the neuroscience function and collaborate with cross-disciplinary teams to advance programs from research to development. Develop forward looking strategies to identify and implement novel assays, measurements, and technologies that increase throughput, quality, and reproducibility of research results. Ensure the quality and effectiveness of key project results through sound design, early risk assessments, and implementation of backup strategies. Provide expert advice and share knowledge with direct reports, peers, and senior management. Provide guidance to develop both the skills and the careers of direct reports. Train and mentor colleagues and assess current and emerging business challenges to achieve organizational goals. Identify and integrate emerging scientific trends from internal and external sources into short-term organizational objectives. Responsible for data management, data QC, and technical report writing. Author regulatory documents in compliance with regulations, including protocols, study reports, relevant sections of investigator brochures and INDs, and other similar documents. Present program updates and research strategies to functional and non-functional leaders as well as potential and existing partners. Maintain awareness of emerging literature and science in the field and author scientific disclosures as needed.
Job Qualifications (minimum Requirements) Extensive experience with neuropharmacological assays, focusing on electrophysiology and in vivo pharmacology in an industrial research environment, with 5-10+ years of experience managing teams and cross-functional projects. Direct experience with peripheral pain animal models and measurements. Proven track record of driving early to late-stage development programs. Extensive knowledge and experience in neuroscience, both central and peripheral. At a minimum, conversant in ion channel biochemistry, toxicology and histological assays and methods. Extremely organized and experienced with documentation of experimental plans, budget, timelines, and technical reports. Experience in authoring and QCing technical reports and regulatory documents. Highly organized and self-directed, capable of leading multiple complex research programs in parallel. Strong understanding of standard statistical analysis of scientific data using data software tools (e.g., Prism, SigmaPlot, and SPSS). Detailed oriented and precise in written and oral communication. Effective problem solving skills. Ability to critically analyze data and lead teams to solve issues and make best strategic decisions. Highly collaborative, team-oriented, and considerate of the needs of others. Strong interpersonal skills and ability to collaborate with diverse groups within the organization and external partners. Knowledge of pharmaceutical development processes, including lead characterization, CMC considerations, and GxP tox & safety. Experience evaluating internal and external research and development programs. Proven team leadership and management abilities, including experience mentoring, guiding, supervising, and developing scientific personnel with various backgrounds and training levels. Ability to create an inclusive environment where diverse ideas, viewpoints and backgrounds are valued; willingness and ability to lead inclusively and demonstrate a commitment to listen and consider all points of view.
Education & Experience PhD and postdoctoral studies in Biology, Neuroscience, Biochemistry, or equivalent field with a robust publication record in leading scientific journals. 5-10+ years of work experience in biotech or pharma with target identification/validation and drug discovery and development.
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